Relapse in children with acute lymphoblastic leukaemia involving selection of a pre-existing drug resistant sub-clone Short title: Clonal selection and relapse in ALL
نویسندگان
چکیده
Children’s Cancer Institute Australia for Medical Research, Sydney, Australia* Telethon Institute for Child Health Research, and Centre for Child Health Research, University of Western Australia, Perth, Australia Oncology Unit, The Children's Hospital, Westmead, Sydney, Australia Department of Haematology–Oncology, Princess Margaret Hospital, Perth, Australia Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital, High St, Randwick, Sydney, Australia
منابع مشابه
Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone.
Relapse following remission induction chemotherapy remains a barrier to survival in approximately 20% of children suffering from acute lymphoblastic leukemia (ALL). To investigate the mechanism of relapse, 27 matched diagnosis and relapse ALL samples were analyzed for clonal populations using polymerase chain reaction (PCR)-based detection of multiple antigen receptor gene rearrangements. These...
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